Nursing mother dogs naturally produce an appeasing pheromone. This pheromone provides reassurance to the puppies, helping them to feel safe and secure when encountering new experiences and unknown environments. Clinical studies have demonstrated that a synthetic analogue of the dog appeasing pheromone (D.A.P.®) helps provide reassurance and comfort to puppies and dogs of all ages. ADAPTIL® contains D.A.P.® and is therefore recommended to help prevent and reduce stress-related behavior in puppies and adult dogs. ADAPTIL® has also helped to make puppies and adult dogs more responsive to behavioral therapy and training. The efficacy of ADAPTIL® has been demonstrated by numerous studies published within reputable scientific journals and presented at international conferences (under the trademark D.A.P.® until 2011).